Increased serum titers of autoantibodies against oxidized LDL cholesterol in young healthy adults.
نویسندگان
چکیده
oxidative modification of low density lipoprotein (LDL) represents a significant parameter in the atheromatous plaque formation. Oxidative modification of LDL takes place in two stages. In the first stage (stage of mild oxidation), lipids of LDL, mainly various pho-spholipids such as phosphatidylcholine, are oxidized without any transformation of the molecular structure of apolipoprotein B-100 (apo-B). In the second stage (stage of advanced
منابع مشابه
بررسی عیار اتوآنتـی بادی علیه انواع LDL تغییر یافته در بیماران مبتلا به بیماری‌های قلبـی عروقـی
Background: Atherosclrosis is a process that initiated with hypercholestrolemia and fatty streak formation. Previous studies showed oxidative modification of LDL render immunogenic and autoantibodies to epitopes of oxidized LDL. Oxidized LDL (OX-LDL), has antigenic properties. Antibodies against oxidized LDL have been proposed to be independent predictors of atherosclerosis development. The mai...
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OBJECTIVE The aim of this work was to investigate the effect of vitamin E (VE) supplementation on the formation of autoantibodies against oxidized low density lipoproteins (LDL) in a hyperlipidemic animal model. METHODS Thirty-four male hamsters (Mesocricetus auratus), (4 weeks old) were divided into three groups: Group A (n=9) was fed with standard rodent chow; group B (n=13) was fed with a ...
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عنوان ژورنال:
- Atherosclerosis
دوره 192 2 شماره
صفحات -
تاریخ انتشار 2007